Purpose: We aimed to investigate the relationship between the staining rates of thrombospondin-1, VEGF and PDGFR-in tissue preparations in patients diagnosed with DLBCL as a result of lymphadenopathy biopsy and their clinical features at the time of diagnosis, response to treatment and prognosis. Materials and Methods: For this purpose, a total of 44 patients with a diagnosis of DLBCL, 24 male and 20 female, and 13 patients diagnosed with control reactive lymphadenopathy, 6 male and 7 female were enrolled. After the pathology preparations of the patient and control groups were stained immunohistochemically with VEGF, PDGFR-β, thrombospondin-1 stains, the clinical characteristics of the patients and the relationship between survival analysis and staining rates were analyzed statistically. Results: When the patients were compared with the control group in terms of VEGF, PDGFR-β, thrombospondin-1 staining rates, we found that staining with PDGFR-β was lower in patients (p = 0.009). Although it was not statistically significant for PDGFR-β, it was observed that 5-year OS and PFS values were low in patients with high levels of expression, on the contrary, 5-year OS was low in patients with high thrombospondin staining rate. A negative correlation was seen between thrombospondin-1 and PDGFR-β (p=0.003, r=-0.440). Conclusion: As a result, although no relationship was found between VEGF and survival in our study, it was observed that PDGFR-β and thrombospondin-1 were effective in prognosis. A negative correlation was seen between thrombospondin-1 and PDGFR-β.