Background: Burkitt lymphoma (BL) is an aggressive non-Hodgkin’s lymphoma (NHL). With high-dose combination chemotherapy cure rates are excellent but associated with higher rates of infections, and morbidity. Treatment for HIV positive Burkitt lymphoma is similar to HIV negative Burkitt lymphoma along with anti-retroviral therapy. In resource constrained setting offering intensive chemotherapy sometime is difficult. There is scarcity of data regarding use of metronomic chemotherapy in aggressive lymphomas. Results: Here we present outcome and review of literature of child, diagnosed with Burkitt lymphoma and HIV who was treated with metronomic chemotherapy. After year of follow-up he is disease free.