The first reported case of Noonan syndrome complicated with hepatocellular carcinoma.

Satoru Kakizaki; Daisuke Uehara; Hiroki Tojima; Takayoshi Suga; Yuichi Yamazaki; Ken Sato; Norio Kubo; Ken Shirabe; Takayuki Yokota; Kei Shibuya; Tatsurou Maehara; Hideaki Yokoo; Atsushi Naganuma; Toshio Uraoka

doi:10.22541/au.161625972.22522023/v1

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The first reported case of Noonan syndrome complicated with hepatocellular carcinoma.

Satoru Kakizaki,
Daisuke Uehara,
Hiroki Tojima,
Takayoshi Suga,
Yuichi Yamazaki,
Ken Sato,
Norio Kubo,
Ken Shirabe,
Takayuki Yokota,
Kei Shibuya,
Tatsurou Maehara,
Hideaki Yokoo,
Atsushi Naganuma,
Toshio Uraoka

Abstract

Noonan syndrome is a genetic multisystem disorder characterized by distinctive facial features, developmental delay, congenital heart disease, and other conditions. It is associated with mutation of genes encoding the proteins in the RAS-MAPK pathway, including PTPN11. We herein describe the first case of Noonan syndrome complicated with hepatocellular carcinoma.

17 Mar 2021Submitted to Clinical Case Reports

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18 Mar 2021Submission Checks Completed

18 Mar 2021Assigned to Editor

20 Mar 2021Reviewer(s) Assigned

31 Mar 2021Review(s) Completed, Editorial Evaluation Pending

06 Apr 2021Editorial Decision: Revise Minor

07 Apr 20211st Revision Received

12 Apr 2021Submission Checks Completed

12 Apr 2021Assigned to Editor

12 Apr 2021Review(s) Completed, Editorial Evaluation Pending

26 Apr 2021Editorial Decision: Accept

Abstract

Peer review status:ACCEPTED