KEY POINTS
- Non-functional larynx (NFL) was found to affect 30.9 % of patients
with locally advanced laryngeal cancer who underwent curative
non-surgical treatment
- The key measures of NFL were long-term gastrostomy and tracheostomy
dependence, functional laryngectomy and chronic aspiration.
- Multivariate analyses identified current smoking to be associated with
6.8-fold increase in NFL
- Patients with pre-treatment hemi-laryngeal fixation were 3.4 times
more likely to experience locoregional recurrence.
- 5-year overall survival, disease free survival and disease specific
survival were 57.6%, 52.1%, 68.4% respectively.