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Spirometry versus Forced Oscillation to Assess Lung Function Outcome at 5-years of Age.
  • +12
  • Robert Tepper,
  • Kristin Milner,
  • Julia Harris,
  • Brianna Lee,
  • Michelle Cunningham,
  • Christina Tiller,
  • Lyndsey E. Shorey-Kendrick,
  • Diane Schilling,
  • Julie Brownsberger,
  • Kelvin MacDonald,
  • Annette Vu,
  • Byung Park,
  • Eliot Spindel,
  • Cynthia D. Morris,
  • Cindy McEvoy
Robert Tepper
Indiana University Department of Pediatrics Division of Pediatric Pulmonology Allergy and Sleep Medicine

Corresponding Author:[email protected]

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Kristin Milner
Doernbecher Children's Hospital Pape Family Pediatric Research Institute
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Julia Harris
Doernbecher Children's Hospital Pape Family Pediatric Research Institute
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Brianna Lee
Doernbecher Children's Hospital Pape Family Pediatric Research Institute
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Michelle Cunningham
Indiana University Department of Pediatrics Division of Pediatric Pulmonology Allergy and Sleep Medicine
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Christina Tiller
Indiana University Department of Pediatrics Division of Pediatric Pulmonology Allergy and Sleep Medicine
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Lyndsey E. Shorey-Kendrick
Doernbecher Children's Hospital Pape Family Pediatric Research Institute
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Diane Schilling
Doernbecher Children's Hospital Pape Family Pediatric Research Institute
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Julie Brownsberger
Doernbecher Children's Hospital Pape Family Pediatric Research Institute
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Kelvin MacDonald
Doernbecher Children's Hospital Pape Family Pediatric Research Institute
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Annette Vu
Oregon Health & Science University
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Byung Park
Oregon Health & Science University
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Eliot Spindel
Oregon Health & Science University Oregon National Primate Research Center
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Cynthia D. Morris
Oregon Health & Science University Department of Medical Informatics and Clinical Epidemiology
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Cindy McEvoy
Doernbecher Children's Hospital Pape Family Pediatric Research Institute
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Abstract

Background: Spirometry is the gold standard for assessing airway function for clinical studies; however, obtaining high quality data in young children remains challenging. Since the forced oscillation technique (FOT) requires less subject cooperations, there has been increasing interest in FOT, particularly in young children. We evaluated whether spirometry and FOT in young children provides comparable ability to detect a treatment effect. Methods: We recently reported in a randomized controlled trial that vitamin C compared to placebo treatment of mothers who smoked during pregnancy (MSDP) results in the offspring having significantly higher forced expiratory flows at 5-years of age, as well as significantly less wheeze at 4-6 years of age. In these same offspring, we also measured FOT at 8-Hz impedance at 3, 4, and 5 years of age. Results: Although spirometry demonstrated significantly increased forced expiratory flows (FEFs) in the vitamin C compared to placebo treatment group at 5-years of age (p < 0.001), we were not able to detect a similar treatment effect using FOT impedance. Conclusions: It may be challenging to obtain technically successful spirometry in pre-school children; however, forced expiratory flows may provide a better outcome than single frequency FOT impedance to assess improvements in airway function in these young subjects.
Submitted to Pediatric Pulmonology
Submission Checks Completed
Assigned to Editor
Reviewer(s) Assigned
29 Jun 2024Reviewer(s) Assigned
28 Jul 2024Review(s) Completed, Editorial Evaluation Pending
29 Jul 2024Editorial Decision: Revise Major
06 Sep 20241st Revision Received
11 Sep 2024Review(s) Completed, Editorial Evaluation Pending
11 Sep 2024Submission Checks Completed
11 Sep 2024Assigned to Editor
11 Sep 2024Reviewer(s) Assigned