4 CONCLUSION
CLA are debilitating chronic diseases that can be life-threatening. Given the progressive nature of these conditions, early and accurate diagnosis is essential for optimal management, which typically requires an interdisciplinary and multimodal approach. Although CLA do not have a cure, recent clinical and scientific discoveries have enhanced our knowledge of the genetics and pathophysiology of these conditions and changed the treatment paradigm, now favoring medical management to control disease progression and complications as well as improve symptoms and QOL.