Study design and subjects
This is a single-center prospective review of the clinical records of patients registered in the iAnet database (UMIN000013561), designed with the cooperation of Hitachi Solutions Create.16
Participants who were born between January 2002 and December 2005, and first visited National Hospital Organization, Sagamihara National Hospital before the age of 6 years with IgE-mediated CMA were included. Patients who tolerated CM or underwent CM-OIT before the age of 6 years, who refused to participate in this study, or who had missing clinical information were excluded. All participants had confirmed sensitization to CM with CM-sIgE levels > 0.35 kUA/L using ImmunoCAPTM (Thermo Fisher Scientific/Phadia, Uppsala, Sweden).