Outcomes
The primary outcome was the rate of CM tolerance acquisition by 12 years
of age when we defined children who enrolled in OIT after the age of 6
years as having persistent CMA. Secondary outcomes were the risk factors
associated with persistent CMA among the children’s characteristics at
the age of 6 years, as well as immunological changes between 6 and 12
years of age. We also calculated the optimal cutoff values for
laboratory parameters associated with persistent CMA. In sub-analysis,
we estimated the rate of CM tolerance acquisition by either defining
children who enrolled in OIT after the age of 6 years as dropouts or by
factoring in the OIT results.