Figure legends
Figure 1. Flow chart of study participant selection.
CMA, cow’s milk allergy; CM-OIT, cow’s milk oral immunotherapy
Figure 2. Kaplan–Meier analysis of the tolerance acquisition rate in children aged 6–12 years with CMA. Patients enrolled in oral immunotherapy after the age of 6 years were considered as having continued elimination of cow’s milk.
CMA, cow’s milk allergy
Figure 3. Kaplan–Meier curves showing CMA tolerance from ages 6–12 years. (A) Grouped by the optimal cutoff value of CM-sIgE levels, as determined by the receiver operating characteristic curve. (B) Grouped by complete elimination of CM by the age of 6 years. (C) Grouped by anaphylaxis to CM prior to the age of 6 years. (D) Grouped by combinations of the two factors, complete CM elimination from the diet and previous anaphylaxis to CM at the age of 6 years. Two of 45 children (4%) with complete CM elimination and previous anaphylaxis, 10 of 36 children (28%) with complete CM elimination but without previous anaphylaxis, 10 of 14 children (71%) with partial CM elimination and previous anaphylaxis, and 24 of 28 children (86%) with partial CM elimination but without previous anaphylaxis acquired tolerance (A-D) Groups are significantly different (p < 0.001, log-rank test).
CM, cow’s milk; CM-sIgE, CM-specific immunoglobulin E; CMA, CM allergy