Follow-up
Children with CMA were annually assessed using CM-sIgE and CM OFC.
According to the Japanese guidelines for food allergies, we performed
stepwise OFC.7, 16 When a child passed an OFC, we
instructed them to consume the amount of CM that was confirmed by the
OFC to be tolerated. Children with complete CM elimination were usually
requested to undergo OFCs. Children who were lost to follow-up between
the ages of 6 and 12 years were considered dropouts.
Detailed methods and eligibility criteria for enrollment in OIT at our
institution are described in the Supplementary information.