Statistical analysis
Values are presented as the median (interquartile range [IQR]). To
analyze the differences between the two groups, we used either the
Mann–Whitney U test or Fisher’s exact test (both two-tailed).
Kaplan–Meier survival curves were generated to depict the acquisition
rate of CMA tolerance. Hazard ratios (HRs) and 95% confidence intervals
(CIs), comparing children with factors affecting persistent CMA, were
determined based on a Cox proportional hazards model. We considered the
number of children to be sufficient to confirm the occurrence of 10 or
more tolerant events per explanatory variable.17 All
statistical analyses were performed using SPSS (version 25.0; IBM Corp.,
Armonk, USA) and GraphPad Prism version 8.0.2 (www.graphpad.com). Ap -value of 0.05 was considered significant. Specific IgE values
to CM and casein < 0.35 kUA/L were considered
as 0.15 kUA/L, and those > 100
kUA/L were considered as 101 kUA/L.