Kaplan–Meier curves grouped by risk factors
Four of 50 children (8%) with a CM-sIgE level ≥ 34.4 kUA/L and 42 of 73 children (58%) with a CM-sIgE level < 34.4 kUA/L acquired tolerance (Figure 3A). Twelve of 81 children (15%) with and 34 of 42 children (81%) without complete CM elimination acquired tolerance (Figure 3B). Twelve of 59 children (20%) with and 34 of 64 children (53%) without previous anaphylaxis to CM acquired tolerance (Figure 3C).
Figure 3D shows the estimated rates of tolerance acquisition grouped by combining the two factors, CM complete elimination and previous anaphylaxis.
In the absence of the three risk factors, 23 of 26 children (88%) acquired tolerance, whereas in their presence, none of the children with CMA (n = 26) acquired tolerance (Supplementary figure 3).