Statistical analysis
Values are presented as the median (interquartile range [IQR]). To analyze the differences between the two groups, we used either the Mann–Whitney U test or Fisher’s exact test (both two-tailed). Kaplan–Meier survival curves were generated to depict the acquisition rate of CMA tolerance. Hazard ratios (HRs) and 95% confidence intervals (CIs), comparing children with factors affecting persistent CMA, were determined based on a Cox proportional hazards model. We considered the number of children to be sufficient to confirm the occurrence of 10 or more tolerant events per explanatory variable.17 All statistical analyses were performed using SPSS (version 25.0; IBM Corp., Armonk, USA) and GraphPad Prism version 8.0.2 (www.graphpad.com). Ap -value of 0.05 was considered significant. Specific IgE values to CM and casein < 0.35 kUA/L were considered as 0.15 kUA/L, and those > 100 kUA/L were considered as 101 kUA/L.