The estimated rates of tolerance acquisition of CMA in children
Twenty-five children (20%) acquired tolerance by 9 years of age, and 46 children (37%) by 12 years of age. Of the 77 remaining children (63%) who were considered to have persistent CMA, 20 (16%) had partially eliminated CM at the age of 12 years, 14 (11%) had completely eliminated CM at this age, and 34 (28%) were enrolled in CM OIT by the age of 12 years (Figure 2).
When we designated children who underwent OIT between the ages of 6 and 12 years as dropouts, the estimated rate of tolerance acquisition by the age of 12 years was 58%. When we defined tolerance acquisition as achieving short-term unresponsiveness to 200 mL of unheated CM for children who underwent OIT after the age of 6 years, the estimated rate of tolerance acquisition by the age of 12 years was 50% (Supplementary figure 1).