Definitions
IgE-mediated CMA was diagnosed by either sensitization to CM and a
history of a convincing immediate-type allergic reaction to CM or
failure in a CM oral food challenge (OFC). Tolerance acquisition was
defined as either passing an OFC of consuming 200 mL of unheated CM or
CM of any quantity without allergic symptoms. Persistent CMA was defined
as fulfilling neither of these criteria by the age of 12 years. Partial
elimination was defined as being able to consume < 200 mL of
CM without allergic symptoms. Children with CMA who were enrolled in CM
oral immunotherapy (OIT) after 6 years of age were defined as having
persistent CMA.