Outcomes
The primary outcome was the rate of CM tolerance acquisition by 12 years of age when we defined children who enrolled in OIT after the age of 6 years as having persistent CMA. Secondary outcomes were the risk factors associated with persistent CMA among the children’s characteristics at the age of 6 years, as well as immunological changes between 6 and 12 years of age. We also calculated the optimal cutoff values for laboratory parameters associated with persistent CMA. In sub-analysis, we estimated the rate of CM tolerance acquisition by either defining children who enrolled in OIT after the age of 6 years as dropouts or by factoring in the OIT results.