Patient 1 2 3 4 5 6 7
Sex Female Male Male Female Male Male Male
Age of onset (months) 7 9 9 6 7 6 7
Age at first visit (months) 9 13 17 16 17 11 8
Fulfilled diagnostic criteria based on history + + + + + +
Fulfilled diagnostic criteria based on OFC +
History of symptoms owing to wheat consumption
Vomiting 2–4 hours after eating a food containing wheat + + + + + + +
Two or more episodes of repetitive vomiting after eating the same food + + + + + + +
Episodes of repetitive vomiting 1–4 hours after eating 2 or more different foods + + + + + +
Number of vomiting episodes before first visit 6 4 3 4 4 2 3
Extreme lethargy with a suspected reaction +
Marked pallor with any suspected reaction + + +
Visit to emergency department due to a suspected reaction +
Requirement of intravenous fluid due to a suspected reaction +
Diarrhea (within 24 hours) + + + + + +
Hypotension +
Hypothermia
IgE-mediated skin and/or respiratory symptoms
Total IgE (IU/mL) 13.2 11.1 <5.0 19.2 7.1 129 12.2
Wheat-sIgE (kUA/L) <0.35 <0.35 <0.35 0.42 <0.35 <0.35 <0.35
ω-5-gliadin sIgE (kUA/L) <0.35 <0.35 <0.35 <0.35 <0.35 <0.35 <0.35
Current complications
Atopic dermatitis + +
Recurrent wheezing
IgE-mediated food allergy
+ (egg)
FPIES (other than wheat)
+ (fish)
+ (barley)
Age at last reaction to wheat (months) 28 14 10 18 19 45 8
Age at which tolerance was confirmed (months) 44 34 42 48 47 NA 13