Identification of genes in common pathways using systems biology
approach
Checking manually for the phenotypic relevance of the 64 genes yielded
nine putative pathways encompassing 41 genes. This can be
directly or indirectly linked to stuttering (table 1). Intriguingly, the
possible candidate genes are different for the two families, but they
fit into nine common pathways. Similarly, pathway browser tool in
Reactome database (https://reactome.org) determine pathways that are
over-represented. In this manner 25 most relevant pathways encompassing
14 genes (table 2), were sorted based on their p-value and the remaining
genes were indicated as interactors (table A3). Thus the enriched gene
list comprised of 14 genes that recurred in the two approaches (tables 1
and 2).