RESULTS
ES is a powerful technology to reveal the complex genetic architecture
and unravel the missing heritability. ES was performed in six
individuals from two highly multiplex families with severe stuttering:
STU-66 nuclear family (figure 1) comprising of affected father (IV-2),
unaffected mother (IV-3), unaffected brother (V-4) and the proband
(V-5); STU-65 family (figure 2) includes two affected siblings
(V-33;V-35). Further details of the families are mentioned in the
methodology section.