RESULTS
ES is a powerful technology to reveal the complex genetic architecture and unravel the missing heritability. ES was performed in six individuals from two highly multiplex families with severe stuttering: STU-66 nuclear family (figure 1) comprising of affected father (IV-2), unaffected mother (IV-3), unaffected brother (V-4) and the proband (V-5); STU-65 family (figure 2) includes two affected siblings (V-33;V-35). Further details of the families are mentioned in the methodology section.