GVHD and Organ Toxicity
Only one patient (patient 1) developed skin symptoms of acute GVHD stage
2-3 during the first 3 months post-transplant. She was treated with
steroids and extracorporeal photopheresis with gradual improvement. She
had no symptoms of chronic GVHD.
Patient 2 developed multiple complications during the first
post-transplantation year: several infections with line sepsis including
disseminated candidiasis with infected thrombus in her right atrium,
requiring prolonged hospitalization for antifungal and anticoagulant
treatment, as well as diabetes mellitus that required insulin treatment.
She developed mild to moderate abnormalities of liver function, most
probably secondary to prolonged TPN.
Patient 3 developed septic shock and multiorgan failure on day +3, and
died on day +12 post-transplantation.
The other patients (4, 5 and 6) had no serious complications related to
transplantation (all data is summarized in Table 2).