Biochemical Correction post-HSCT
Patients 1, 2 and 4, who maintained 100% chimerism, also showed sustained biochemical correction post-HSCT (normal deoxyuridine and thymidine levels in blood). Patient 3, who died 12 days after transplant, showed no biochemical correction. For patients 5 and 6 who had secondary engraftment failure, whereas 23 days post-transplant patient 5 had essentially normal results, nucleoside levels 18 and 14 months post-transplant, respectively, were elevated (all details are summarized in Table 2).