CONCLUSIONS
By using a transgenic B. mori system, we synthesized the modified silk fibroin TiBP-SF, which is doped with an artificial protein composed of silk fibroin motif (AGSGAG) and titanium binding motif (RKLPDAS) in the [TS[(AGSGAG)3AS]2RKLPDAS]8formula. The TiBP-SF enhanced the ossific differentiation of osteoblast-like cells when coated on the surfaces of a titanium plate. Accordingly, TiBP-SF has potential applications in the medical field.