Hepatic cirrhosis is a very rare complication of hematopoietic stem cell transplantation (SCT) and of neuroblastoma. We encountered two patients developing cirrhosis after SCT against neuroblastoma. A 6-year-old boy who had received allogeneic bone marrow transplantation developed cirrhosis 10 years after the SCT with the massive upper gastrointestinal hemorrhage. A 27-year-old man receiving allogeneic cord blood transplantation against recurrence of neuroblastoma, died of liver failure due to histological cirrhosis 1 year after the SCT. We could not detect the definite etiologic candidates of cirrhosis; however, careful monitoring appears warranted to avoid overlooking the onset and progression of cirrhosis after SCT.