A recently proposed risk stratification of medulloblastomas has shown that Sonic Hedgehog (SHH) subtype with TP53 mutation is the worst prognostic. Here, we describe the case of a 6-year-old boy with clinically very aggressive SHH medulloblastoma like TP53 mutant, but the genetic status of the case was wild type. Copy number analysis showed MYCN amplification, chromosome 17p loss, and chromothripsis, which are known to be strongly associated with TP53-mutated SHH tumors. The presence of both chromosome 17p loss and chromothripsis in SHH medulloblastoma may suggest a p53 pathway dysregulation regardless of the TP53 status, leading to a much worse prognosis.