Material and Method
In our study between 2011-2019, among the 1393 kidney biopsy samples of 80 samples belong to diabetic patients. These 70 diabetic patients older than 18 years were evaluated retrospectively. There were 38 DN, 32 PGN, and 10 DN with superimposed diseases (such as DN + hypertensive nephropathy, DN + crescentic GN) according to kidney biopsy. Ten patients with superimposing conditions with DN were excluded from the study.
Clinical-demographic characteristics, treatment, and laboratory results of the patients were obtained from the medical records of our hospital.
Clinical-demographic characteristics; age, gender, body mass index, smoking, blood pressure, DM duration, accompanying diseases (Hypertension (HT), coronary artery disease (CAD), heart failure), diabetic microvascular complications (diabetic retinopathy (DR), diabetic neuropathy ( DNP)) and drugs used (ACEI (angiotensin-converting enzyme inhibitor), ARB (Angiotensin receptor blocker), oral antidiabetic, Insulin) were evaluated.
At the time of kidney biopsy and follow up period at 6. and 12 months; biochemical parameters including fasting blood sugar, blood urea nitrogen, creatinine, total protein, albumin, AST, ALT, sodium, potassium, calcium, phosphorus, total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, complete blood count, HbA1C, proteinuria in 24-hour urine and glomerular filtration rate (eGFR) were recorded. eGFR was calculated according to CKD-EPI8. ADA (American Diabetes Association) criteria were used in the diagnosis of type 2 DM9. AHA criteria were used for heart failure10.
The diagnosis of DR was made by fundoscopy and/or fluorescein angiography, and DNP was made by electromyogram (EMG). Patients using antihypertensive drugs or blood pressure ≥ 140/90 were considered hypertensive.