Introduction
Diabetic Nephropathy (DN) is the most common cause of renal involvement in diabetic patients. It causes renal histopathological changes such as glomerular basement membrane thickening, mesangial matrix increase, diffuse or nodular glomerulosclerosis1. Typically, early-stage hyperfiltration develops, followed by microalbuminuria and macroalbuminuria, with slow progressive renal dysfunction. Ultimately, it causes end-stage kidney disease (ESRD)2. Non-diabetic kidney disease (NDKD) prevalence may vary depending on renal biopsy selection criteria, and its frequency shows significant variations3. In renal biopsy samples of diabetic patients, 1/3 DN only, 1/3 NDKD, and 1/3 DN and disease have been reported4,5. Renal biopsy in diabetic patients is performed in suspicious cases, not routinely6. The diagnosis of NDKD is closely related to clinical findings, clinician opinion, and center experience. Besides, its treatment and prognosis are quite different from DN. In a diabetic patient, sudden onset proteinuria, the rapid loss of kidney function, active urinary sediment, and the short-term history of DM may be clues for additional pathologies3,7.
Retrospective single-center study, we investigated the clinical, laboratory, and pathological differences of patients with biopsy-proven DN and PGN patients with type 2 DM.