ABSTRACT: Objective To investigate the Aneurysmal of the left sinus of Valsalva, and to improve the understanding of the disease and the level of diagnosis and treatment. Methods This article mainly reports a case of huge Aneurysmal of the left sinus of Valsalva patients treated with surgical treatment. Results After surgery, the prognosis of the case was good. Conclusion Aneurysmal of the left sinus of Valsalva has low incidence,which is rare in clinical with no clinical specific symptoms leading to difficulty in early detection. The appropriate surgical method should be considered to the patient condition, to prevent the tumor rupture and the death of patients.