Figure 1. The figure schematizes the relationship between diabesity- the association of obesity and diabetes- and SARS-CoV-2 infection response. Diabesity increases the susceptibility to exacerbation of COVID-19 throughout an excessive metabolic inflammatory response (metaflammation) that is regulated, at least in part, by the NLRP3 inflammasome complex. NLRP3 is also a master regulator of the cytokine storm and pyroptosis, both evoked by SARS-CoV-2 infection.