In patients presenting with transient ischaemic attack and acute minor noncardioembolic ischemic stroke (NIHSS score ≤3) who did not receive IV alteplase, treatment with dual antiplatelet therapy with aspirin and clopidogrel, started within 24 hours after symptom onset and continued for 21 days is effective in reducing recurrent ischemic stroke up to 90 days from symptom onset. However, as the long-term risk of major disabling bleeding with aspirin-based antiplatelet treatment is higher in patients aged 75 years or older, routine co-prescription of proton pump inhibitor should be encouraged.