Empirical evaluation of fundamental principles of evidence-based
medicine: a meta-epidemiological study
Benjamin Djulbegovic, MD, PhD1, Muhammad Muneeb Ahmed,
MS2, Iztok Hozo, PhD3, Despina
Koletsi, DDS4, Lars Hemkens, MD5,
Amy Price, PhD6, Rachel Riera,MD7,
Paulo Nadanovsky,MD8, Ana Paula Pires dos
Santos,MD9, Daniela Melo,MD10,
Ranjan Pathak,MD11, Rafael Leite
Pacheco,MD12, Luis Eduardo
Fontes,MD13 and David Nunan,PhD14
1 Beckman Research Institute, Department of
Computational & Quantitative Medicine, City of Hope, Duarte,
California, USA
2Michael G. DeGroote School of Medicine, McMaster
University, Hamilton, Ontario, Canada
3Department of Mathematics, Indiana University
Northwest, Gary, Indiana, USA
4Clinic of Orthodontics and Pediatric Dentistry,
Center of Dental Medicine, University of Zurich, Switzerland
5Department of Clinical Research, University of Basel,
Basel Institute for Clinical Epidemiology & Biostatistics, University
Hospital Basel, Switzerland.
6Anesthesia Informatics and Media Lab, Stanford
University, Stanford, California, USA
7Universidade Federal de São Paulo, Escola Paulista de
Medicina, Brazil (Unifesp), São Paulo, Brazil
8Department of Epidemiology and Quantitative Methods
in Health, National School of Public Health, Fundação Oswaldo Cruz
(FIOCRUZ) - Department of Epidemiology, Institute of Social Medicine,
Universidade do Estado do Rio de Janeiro (UERJ).
9Department of Community and Preventive Dentistry,
Faculty of Dentistry, Universidade do Estado do Rio de Janeiro (UERJ).
10Department of Pharmaceutical Sciences, Universidade
Federal de São Paulo (Unifesp), Brazil.
11Department of Medical Oncology and Therapeutics
Research, City of Hope, Duarte, California, USA.
12Centro Universitário São Camilo. Researcher at the
Center of Health Technology Assessment. Hospital Sirio-Libanês - São
Paulo, Brazil
13 Department of Intensive Care, and Emergency
Medicine at Faculdade de Medicina de Petrópolis, in Petrópolis, Rio de
Janeiro, Brazil.
14Nuffield Department of Primary Care Health Sciences,
Oxford University, Oxford, UK
Word count:
Abstract: 336
Main text: 3,321
Correspondence: Benjamin Djulbegovic, MD, PhD
1500 E Duarte Road
Duarte, CA 91010-3000
Phone: 626-218-7502
e-mail:
bdjulbegovic@coh.org