Statistical Analysis:
 Statistical analysis was performed with Medcalc 19.0 (R) and SPSS version 25.0 software (IBM SPSS Statistics, IBM Corporation, Armonk, New York) statistical program. Distribution normality was tested by the Shapiro Wilk test. Continuous variables are calculated as mean, SD, or median (IQR), and categorical variables as counts and percentages. Comparisons between groups were performed with a two-sided Studentt -test, Wilcoxon-Mann-Whitney U test, and chi-square or Fisher exact test for categorical variables. Values of p <0.05 were accepted to be statistically significant.
The follow-up duration is determined using the index date to the first MACE date or the last follow-up of patients. Survival curves compared with the log-rank (Mantel-Cox) test for defined primary end-points.