Abstract
Optineurin (OPTN) is a multifunctional adaptor protein that mainly
involved in autophagy. While it was defined as an autophagy receptor and
inducer, the extensive and important role in autophagy is hardly
mentioned. What’s more, there are some critical disorders are closely
related to OPTN, such as Glaucoma, Amyotrophic lateral sclerosis,
Paget’s disease of bone, Crohn’s disease, cancer and diabetic
nephropathy. This review will depict the OPTN involved autophagic
process, from the recognition of cargo to the degradation in the
autolysosome in molecular terms, and in particular highlight the process
that compromised in disease related to OPTN. And we looking forward to
strategies to modulate OPTN specifically with no toxic effects so that
establish an efficient therapy for autophagy defective diseases.