Acute respiratory distress syndrome (ARDS) is the key cause for the morbidity and mortality due to COVID-19 infections. Recent clinical evidences suggest chronic release of pro-inflammatory cytokines as a prominent etiological factor. Adult stem cells are known to secrete potent immunomodulatory and bioactive compounds. We propose a nebulizer assisted treatment of Mesenchymal Stem Cells (MSCs) Secretome as a therapy which will counterbalance the COVID-19 induced cytokine storm as well as promote the regeneration of alveolar tissue attributed to the intrinsic cytokines and growth factor present in the Secretome. Intranasal administration of Secretome will not only protect against the COVID-19 associated complications but also bring down the necessity of the ventilator reducing the burden on health care infrastructure.