Although it seems that the COVID-19 is not as fatal as SARS and MERS, its highly contagious nature have made it a more serious health concern. This new pandemic has affected all aspects of human life, and due to the vast diversity in the nations around the world, it is not possible to adopt a single integrated policy aginst the disease. It is deemed that the outbreak of the COVID-19 potentially can affect the geopolitical dynamics of the world. Thus, considering the unique context of the Middle East, and its impact on many other countries, here we tried to compare the case fatality rate (CFR), the disease rate (DR), and the crude death rate (CDR) for all the countries located in this region with the top-ten most affected until April 25, 2020. Special attention was also paid to discuss the data obtained in our study with the existing literature. We aimed to explain the effect of significant cultural and ideological differences, the enormous differences among the health systems of the countries, and the efficacy of the governmental mitigation policies on the variability of the epidemiological factors among the 25 countries included in our list. Speed of action in disease control and high level of testing in Germany, a sizable population of homeless people in the U.S., the concurrencey of Influenza A, Influenza B, and the COVID-19 in France, a relatively low hospital capacity in the U.K., the numerous mass demonstrations in Spain, the effect of tough sanctions against Iran, the high number of tourists traveling to Turkey, the coincidence of Middle East respiratory syndrome (MERS) and COVID-19 in Saudi Arabia, the complicated military dominance in Egypt, as well as the effect of religious mass gathering in the Muslim countries were some factors which helped us to explain our results.