# P<0.05 and ### P<0.001 vs. C- (statistical analysis assessed by Student’s t-test); *P<0.05, ** P<0.01, and *** P<0.001 vs. C+ (statistical analysis assessed by one-way ANOVA); data represent the mean±SEM of n=5 bronchial tissue from different subjects. C+: positive control, passively sensitized bronchi; C-: negative control, non-sensitized bronchi; CRC: concentration-response curve; EC₅₀: concentration inducing 50% E_max; E_max: maximal effect; pEC₅₀: -LogEC₅₀.

Table 2. Efficacy and potency of benralizumab and mepolizumab after overnight incubation on the AHR to different concentrations of histamine (EC_50-90) in passively sensitized bronchi. The pharmacological analysis was performed by assessing E_maxas the difference in airway contractility between C+ and C- tissues.