* P<0.05 and ** P<0.01 vs. mepolizumab (statistical analysis assessed by Student’s t-test); data represent the mean±SEM of n=5 bronchial tissue from different subjects. AHR: airway hyperresponsiveness; C+: positive control, passively sensitized bronchi; C-: negative control, non-sensitized bronchi; ECn: concentration inducing n% Emax; Emax: maximal effect; IC50: concentration inducing 50% inhibition AHR to histamine in passively sensitized bronchi; pIC50: -logIC50.