C- C+ Benralizumab Benralizumab Benralizumab Benralizumab Benralizumab Mepolizumab Mepolizumab Mepolizumab Mepolizumab Mepolizumab
1 μg/ml 3 μg/ml 10 μg/ml 30 μg/ml 100 μg/ml 1 μg/ml 3 μg/ml 10 μg/ml 30 μg/ml 100 μg/ml
Histamine Emax (mg/100mg bronchial tissue) 996.80±100.00 1857.00±171.60 ### 1510.00±109.00 *** 1342.00±86.58 *** 1244.00±127.70 *** 848.30±160.00 *** 524.90±80.07 *** 1822.00±145.80 1394.00170.70 ** 1145.00±125.40 *** 1006.00±149.80 *** 1008.00±442.40 ***
Histamine pEC50 5.49±0.15 6.15±0.17 # 5.75±0.18 5.80±0.18 5.51±0.19 * 5.55±0.16 * 5.50±0.20 * 6.30±0.30 6.09±0.47 5.82±0.31 5.92±0.36 5.50±0.22 *