Stress cardiomyopathy (SC) is a syndrome characterized by transient regional systolic dysfunction of the left ventricle (LV), in the absence of obstructive coronary artery disease. The diagnosis of SC represents a challenge as it is essentially a diagnosis of exclusion. We report the case of a 21-year-old man who sustained mid-ventricular (MV) SC after a seizure. Our case represents a combination of a predisposing acute neuronal injury in a man that led to the development of an MV SC variant, where cardiac MRI played an essential role in the diagnosis.