Functions enriched within adaptive genomic regions
The mammalian phenotype terms showed some significant tests for enrichment based on the overlap of annotated genes from the four chromosome regions (Table S11). The top three terms with lowest P-value from our list of 98 candidate genes on chromosome 01 (which is associated with maturity) were abnormal social investigation, abnormal blood urea nitrogen level, and induced hyperactivity. The three top terms output for our list of 260 genes on chromosome 02 (which is associated with body size traits) were short tibia, decreased brown fat cell lipid droplet size, and Purkinje cell degeneration. The phenotypes in fishes did not show significant Fisher’s exact tests for enrichment of terms, although for chromosome 01, the top three ranked phenotypic terms (based on combined score, Chen et al. 2013) may be relevant to the associations we observed in this study. These terms were reproductive behavior, response to absence of light, and entrainment of circadian clock by photoperiod (Table S12).