The host-pathogen combinations - Malus domestica (apple)/´Candidatus Phytoplasma mali´, Prunus persica (peach)/‘Ca. P. prunorum´ and Pyrus communis (pear)/‘Ca. P. pyri´ show different course of diseases although the phytoplasma strains belong to the same 16SrX group. While infected apple trees can survive for decades, peach and pear trees die within some weeks to few years period. So far, in these phytoplasma-plant interactions neither morphological nor physiological differences have been studied in the hosts. Phytoplasma-induced morphological changes of the vascular system as well as physiological changes of the phloem sap and leaf phytohormones were analysed and compared with non-infected plants. Unlike peach and pear, infected apple trees showed substantial reductions in leaf and vascular morphology, causing negative effects on phloem mass flow. In contrast, in pear mass flow and physicochemical characteristics of phloem sap increased. No changes in phytohormone levels were detected in pear but in apple and peach trees, where defence- and stress-related phytohormones increased. If compared with peach and pear trees, the data from apple suggest that the long-lasting morphological adaptations in the vascular system, which likely cause reduced sap flow, triggers the ability of apple trees to survive phytoplasma infection. Some phytohormone-mediated defences might support the tolerance.