Regulated or programmed cell death play a critical role in development and tissue organization and function. In addition, it is intrinsically connected with immunity and host defense. Increasing cellular and molecular findings are changing the concept of cell death, revealing an expanding network of regulated cell death modalities and their biochemical programs. Likewise, recent evidences are demonstrating the interconnection between cell death pathways and how they are involved in different immune mechanisms. This work provides an overview of the main cell death programs and their implication in innate immunity not only as an immunogenic/inflammatory process, but also as an active defense strategy during immune response and at the same time, as a regulatory mechanism.