Contribution statement:
KN, QX, KKC, and JW conceived the research question. JW defined the
question, designed the study, and conducted data analysis. KN and MJP
advised on study design and contributed to data analysis. KKC, HX, and
QX provided input for study design. YK, JH, SS, JL, and JW contributed
to the sample collection, storage, and biochemical tests, and data
pre-processing. MP checked the ABN analysis externally. All authors
contributed to the interpretation of the results. JW led the writing of
the manuscript with critical input from all other authors. JW, XQ, and
KN had full access to all data (including statistical reports and
tables) in the study and can take responsibility for the integrity of
the data and the accuracy of the data analysis. JW is the guarantor.
Data sharing: No
additional data available.
Transparency: The lead author (JW) affirms that this manuscript
is an honest, accurate, and transparent account of the study being
reported; that no important aspects of the study have been omitted; and
that any discrepancies from the study as planned (and, if relevant,
registered) have been explained.
Ethical approval: Consent has been obtained from each patient
or subject after full explanation of the purpose and nature of all
procedures used.