Contribution statement:
KN, QX, KKC, and JW conceived the research question. JW defined the question, designed the study, and conducted data analysis. KN and MJP advised on study design and contributed to data analysis. KKC, HX, and QX provided input for study design. YK, JH, SS, JL, and JW contributed to the sample collection, storage, and biochemical tests, and data pre-processing. MP checked the ABN analysis externally. All authors contributed to the interpretation of the results. JW led the writing of the manuscript with critical input from all other authors. JW, XQ, and KN had full access to all data (including statistical reports and tables) in the study and can take responsibility for the integrity of the data and the accuracy of the data analysis. JW is the guarantor.
Data sharing: No additional data available.
Transparency: The lead author (JW) affirms that this manuscript is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as planned (and, if relevant, registered) have been explained.
Ethical approval: Consent has been obtained from each patient or subject after full explanation of the purpose and nature of all procedures used.