We report a 54-year-old man with treatment-resistant depression (TRD) and hypothyroidism who responded to LT3/LT4 combination, rather than LT4 alone. He was able to discontinue all antidepressant medications eventually. Interestingly, the patient has a DIO2 polymorphism.

Hepatic epithelioid angiomyolipomas are uncommon mesenchymal neoplasms. They are difficult to diagnose by imaging, especially when the fatty component is scant or absent. The gold standard for the diagnosis is histologic examination coupled with an immunohistochemical study. Positive HMB-45 immunostaining of the myoid cells is a major diagnostic feature.

Some peritoneal dialysis catheter infections cannot be detected via a physical examination. Ultrasonography can aid in the diagnosis of such infections.

Helminths are an important cause of infection in poorly developed countries. The Majority spread with soil to skin contact. In unusual patients presenting below 1 year, treatment can be challenging. The disease can be self-limiting, treatment reduces progression to serious disease. Here, we present a three-month-old with Cutaneous Larva Migrans.

A middle-aged Sudanese woman has been presented complained about multiple joint pain, skin rash, chest pain, hair loss, severe abdominal pain associated with abdominal distension, bloody diarrhoea and vomiting. Lab investigation and computed tomography (CT) abdomen revealed the patient have an intussusception on top of SLE. The patient was treated

We present a case of a 37-year-old woman referred to our hospital with a 1-week history of significant weakness, anorexia, and mild abdominal pain. According to laboratory and radiographic data, the patient was diagnosed with perforated appendicitis and gangrene.

Tachycardia and atrial fibrillation are cardiovascular symptoms of Graves’ hyperthyroidism， if left untreated and further deterioration can result in heart failure and liver dysfunction, we describe a female patient to present the continuum of the pathophysiology development, to highlight the hemodynamic variation is dominant contributing factor of Graves’ hyperthyroidism complication

Covid-19 infection may have extrapulmunary manifestations such as blood hypercoagulability that may causes thrombosis in both arterial and venous system.Deep dorsal penile vein thrombosis is very rare and the most common cause is coagulation disorders.It causes penile pain especially during erection and it is diagnosed by ultrasound.

CRPS is a type of severe pain syndrome and can be triggered by previous surgery or trauma. CRPS type II is associated with a confirmed nerve injury. We want to present to your attention a case report of successful treatment of CRPS type II using unilateral epidural stimulation.

Linear IgA/IgG bullous dermatosis (LAGBD) is a rare, autoimmune blistering skin disease. We report a case of LAGBD in a 70-year-old woman. All common treatments were discontinued due to side effects or lack of treatment response. The patient was successfully treated with omalizumab which cleared her lesions after three months.

Thymomas are tumours frequently associated with autoinmune manifestations or immunodeficiencies like Good syndrome. In rare cases, pure white cells aplasia (PWCA) has been described in association with thymomas. PWCA is characterized by agranulocytosis of autoinmune background primary refractory to granulocyte colony-stimulating factor (G-CSF). It is necessary to use inmunosupressor drugs.

Carotid web has been identified as one of the missed causes of recurrent stroke. The diagnosis and management of such cases, impose a challenge to medical practitioners. This etiology should be kept in mind, especially in case of recurrence of stroke in a similar cerebral territory.

A 20-year-old girl referred with vision loss upon closantel use. Plasma exchange and high-dose corticosteroid pulse therapy were administered. A 2.5-year follow-up showed improved vision and increased layer thickness of the peripheral nerve fiber. Early treatment with plasma exchange and high-dose corticosteroid therapy can be beneficial to reverse closantel toxicity.

The decline in cardio-respiratory function is rising among COVID-19 survivors amid the pandemic. Cardiopulmonary rehabilitation is known to be clinically effective but no studies show data to substantiate its application. The simultaneous treatment improved cardiopulmonary clinical indicators in our patient yielding enhanced functional restoration to enable independent community participation.

Invasive cribriform carcinoma is a rare type of invasive breast carcinoma, and few cases have been reported. Its features are a cribriform pattern resembling the histological structures of cribriform ductal carcinoma in situ and an excellent prognosis. However, the extent of progress for intraductal extension must be carefully evaluated.

Hemorrhagic chronic radiation proctitis (CRP) refractory to endoscopic therapy is rare. Because of its high morbidity and mortality rates, proctectomy is considered as the last resort. We report the successful treatment of severe hematochezia refractory to endoscopic therapy and diverting colostomy in a patient with CRP via rectal irrigation.

Since the start of the COVID‐19 vaccinations, many dermatological manifestations have been described .There are certain safety-related events that, due to rarity, might be detected only during the mass vaccination programs. Here we report a potentially serious adverse effect of Covid vaccines that have been rarely reported before

Chorioamnionitis, a common complication of pregnancy is associated with significant maternal, perinatal, and long-term adverse outcomes. This case of placental infection leading to preterm delivery, severe neonatal sepsis, maternal wound infection, postnatal readmission, and prolonged hospital stay was caused by multi-drug resistant Extended Spectrum Beta Lactamase (ESBL)-producing Escherichia Coli