Seismic anisotropy, observed in the lowermost mantle near Large Low-Shear-Velocity Provinces (LLSVPs), is likely caused by strong deformation from mantle flow interacting with these regions or plume formation. This study explores slab-induced plume generation from thermochemical piles (LLSVPs) and resulting flow behavior using 3-D regional-scale mantle convection models in ASPECT, coupled with mantle fabric simulations in ECOMAN. Various models with different LLSVP density and viscosity were tested. The modeling of the lattice preferred orientation with predominant activity of the slip system [001](100) for Bridgmanite and [100](001) for post-Perovskite reveals that the lower mantle is generally isotropic, except (i) in regions of plume conduits where vertically polarized shear waves (Vsv) are faster, and (ii) in the lowermost mantle characterized by fast horizontally polarized shear waves (Vsh) that transition to fast Vsv at the margins of the rheologically stiffer LLSVP piles where deformation and upwelling of the surrounding mantle take place.