Land reclamations influence the morphodynamic evolution of estuaries and tidal basins, because an altered planform changes tidal dynamics and associated residual sediment transport. The morphodynamic response time to land reclamation is long, impacting the system for decades to centuries. Other human interventions (e.g., deepening of fairways or port construction) will add more morphodynamic adaptation timescales. Our understanding of the cumulative effects of anthropogenic interference with estuaries is limited because observations usually do not cover the complete morphological adaptation period. We aim to assess the impact of land reclamation works and other human interventions on an estuarine system by means of digital reconstructions of historical morphologies of the Ems Estuary over the past 500 years. Our analysis demonstrates that the intertidal-subtidal area ratio altered due to land reclamation works and that the ratio partly restored after land reclamation ended. The land reclamation works have led to the degeneration of an ebb and flood channel system, transitioning the estuary from a multichannel to a single-channel system. We infer that the 20th-century intensification of channel dredging and re-alignment works accelerated rather than caused this development. The centennial-scale observations show that the Ems estuary evolution corresponds to a land reclamation response following tidal asymmetry-based stability theory as it moves towards a new equilibrium configuration with modified tidal flats and channels. Considering the long history of land reclamation in the Ems Estuary, it provides an analogy for expected developments in comparable tidal systems where land reclamations were recently carried out