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The relationship between serum levels of thyroglobulin antibody and the risk of recurrence in patients with differentiated thyroid cancer
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  • F Amirian,
  • Mohammad ali Yaghoubi,
  • Hassan Mehrad-Majd,
  • M Mohebbi,
  • P Layegh,
  • LV Mostaan,
  • MM Dadgar,
  • Z Amirian,
  • Ghazale Taghavi
F Amirian
Ghaem Educational Research and Treatment Center
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Mohammad ali Yaghoubi
Mashhad University of Medical Sciences
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Hassan Mehrad-Majd
Mashhad University of Medical Sciences
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M Mohebbi
Mashhad University of Medical Sciences
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P Layegh
Metabolic Syndrome Research Center (MSRC)Mashhad University of Medical Sciences
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LV Mostaan
Mashhad University of Medical Sciences
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MM Dadgar
community medicine departmentschool of medicine
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Z Amirian
University of Medicine
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Ghazale Taghavi

Corresponding Author:[email protected]

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Abstract

Objective: Thyroid Autoantibodies (TgAbs) are associated with autoimmune thyroid disorders and are also used in thyroid cancer follow-up to monitor for recurrence of disease. This study aimed to explore the potential utility of TgAbs as a surrogated tumor marker and examine the relationship between fluctuations in TgAbs levels and disease recurrence in patients with Differentiated Thyroid Cancer (DTC). Method: This cohort study was conducted on a sample of 97 patients who underwent thyroidectomy for differentiated thyroid cancer (DTC) between the years 2017 and 2021. Following surgery (with or without lymph node dissection), levothyroxine therapy and 131 iodine were prescribed (as necessary). Regular laboratory evaluations were conducted, which involved measuring Tg and TgAb at 3 and 6 months postoperatively. Patients were classified based on recurrence rate and different levels of TgAb and ROC analysis was applied. All data were analyzed with SPSS24, and a p-value <0.05 was considered statistically significant. Results: For low-risk patients, TgAb trends over time showed an increase at 6 months, while for high-risk patients, TgAb levels continuously rose starting from 3 months. Although TgAb levels above the functional sensitivity threshold did not predict recurrence overall, changes in TgAb levels at 6 months compared to 3 months after surgery were indicative of recurrence. Conclusion: In the entire population, having TgAb levels higher than the functional sensitivity threshold had not risk of various relapses. However, changes in TgAb serum levels at 6 months after surgery, compared to 3 months after surgery, can serve as an indication of tumor recurrence.
31 May 2024Submitted to Cancer Reports
26 Jun 2024Review(s) Completed, Editorial Evaluation Pending
03 Jul 2024Reviewer(s) Assigned
13 Sep 2024Editorial Decision: Revise Major
05 Oct 20241st Revision Received
09 Oct 2024Submission Checks Completed
09 Oct 2024Assigned to Editor
09 Oct 2024Review(s) Completed, Editorial Evaluation Pending
18 Oct 2024Reviewer(s) Assigned