Statin prescription intensity, defined by statin type and dose required to achieve a targeted decrease in plasma low-density lipoprotein-cholesterol (LDL-C), has been involved in statin-associated muscle symptoms (SAMS) development. This study aimed to assess whether muscle function improved differentially according to treatment intensity after two months of statin withdrawal in patients self-reporting SAMS. Patients (53.0±8.4 years [Mean±SD]) undergoing primary cardiovascular prevention were divided in two groups: low to moderate (n=49, targeted plasma LDL-C reduction <50%) and high (n=12, ≥50%). Strength, endurance, and power in extension and flexion of the dominant leg, and handgrip strength were measured using dynamometers. SAMS intensity was assessed using a 0-10 visual analog scale. After withdrawal, repeated-measures analyses showed improvements for 7/8 performance variables (+7.2 to +13.3%, all p<0.05), concomitant with a decrease in SAMS intensity (5.09 to 1.85, p<0.01), with no between-group difference. The improvement of muscle function following withdrawal was not differentiated according to treatment intensity.