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javascript:void(0) Targeting cell death: a potential therapeutic strategy for inflammatory bowel disease and colorectal cancer
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  • Tian-gang LI,
  • Ying-li Wu,
  • Yin-ying Wang,
  • Peng-tao Liang,
  • Biao-hua Chen,
  • Yuan-jie Fu,
  • Ying Wang,
  • Wen-yuan Li,
  • Jia-li Yuan,
  • Li LI,
  • Jin-yuan Yan,
  • Yong Qiu,
  • Zhong-shan Yang
Tian-gang LI
Yunnan University of Traditional Chinese Medicine
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Ying-li Wu
Yunnan University of Traditional Chinese Medicine
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Yin-ying Wang
Yunnan University of Traditional Chinese Medicine
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Peng-tao Liang
Yunnan University of Traditional Chinese Medicine
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Biao-hua Chen
Yunnan University of Traditional Chinese Medicine
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Yuan-jie Fu
Yunnan University of Traditional Chinese Medicine
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Ying Wang
Yunnan University of Traditional Chinese Medicine
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Wen-yuan Li
Yunnan University of Traditional Chinese Medicine
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Jia-li Yuan
Yunnan University of Traditional Chinese Medicine
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Li LI
Yunnan University of Traditional Chinese Medicine
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Jin-yuan Yan
Kunming Medical University Second Hospital
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Yong Qiu
Yunnan University of Traditional Chinese Medicine
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Zhong-shan Yang
Yunnan University of Traditional Chinese Medicine

Corresponding Author:[email protected]

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Abstract

not-yet-known not-yet-known not-yet-known unknown Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestines characterized by a progressive and unpredictable course, and colorectal cancer (CRC), a malignant tumor of the colon or rectum, is a malignant disease that seriously affects human health. The risk of colitis-associated cancer (CAC) is high in patients with IBD, and CRC is one of the most serious consequences for patients with IBD. Cell death is a fundamental physiological process in all living organisms, and it includes apoptosis, necroptosis, pyroptosis, autophagy, ferroptosis, and cuproptosis. Regulatory cell death (RCD), a form of cell death that can be regulated by a variety of biomolecules, plays an important role in maintaining physiological homeostasis in the body, resistance to pathogen attack, and a range of pathological states, such as inflammation and cancers. There is growing evidence that different types of RCD are involved not only in the pathogenesis of IBD, CRC, and CAC but also in the therapeutic process. The present review will provide ideas for further exploration of RCD affecting IBD, CRC, and CAC by summarizing the possible mechanisms of the involvement of different types of RCD in IBD, CRC, and CAC. Additionally, this article will discuss recent advancements in pharmacotherapy.
28 Aug 2024Submitted to Immunity, Inflammation and Disease
31 Aug 2024Submission Checks Completed
31 Aug 2024Assigned to Editor
02 Sep 2024Reviewer(s) Assigned