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Metabolic Reprogramming in Cancer: Implications for Immunosuppressive Microenvironment
  • Durre Aden,
  • Samreen Zaheer,
  • Sufian Zaheer
Durre Aden
Jamia Hamdard
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Samreen Zaheer
Aligarh Muslim University
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Sufian Zaheer
Vardhman Mahavir Medical College and Safdarjung Hospital

Corresponding Author:[email protected]

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Abstract

Cancer is a complex and heterogeneous disease characterized by uncontrolled cell growth and proliferation. One hallmark of cancer cells is their ability to undergo metabolic reprogramming, which allows them to sustain their rapid growth and survival. This metabolic reprogramming creates an immunosuppressive microenvironment that facilitates tumour progression and evasion of the immune system. In this paper, we review the mechanisms underlying metabolic reprogramming in cancer cells and discuss how these metabolic alterations contribute to the establishment of an immunosuppressive microenvironment. We also explore potential therapeutic strategies targeting metabolic vulnerabilities in cancer cells to enhance immune-mediated anti-tumour responses.
18 May 2024Submitted to Immunology
21 Jul 2024Review(s) Completed, Editorial Evaluation Pending
26 Jul 2024Editorial Decision: Revise Minor
31 Aug 20241st Revision Received
10 Sep 2024Submission Checks Completed
10 Sep 2024Assigned to Editor
10 Sep 2024Review(s) Completed, Editorial Evaluation Pending
11 Sep 2024Reviewer(s) Assigned
30 Sep 2024Editorial Decision: Revise Minor
06 Oct 20242nd Revision Received
07 Oct 2024Submission Checks Completed
07 Oct 2024Assigned to Editor
07 Oct 2024Review(s) Completed, Editorial Evaluation Pending
09 Oct 2024Editorial Decision: Accept