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Balancing brain metabolic states during sickness and recovery sleep
  • +2
  • Sara Noya,
  • Arjun Sengupta,
  • Zhifeng Yue,
  • Aalim Weljie,
  • Amita Sehgal
Sara Noya
University of Pennsylvania
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Arjun Sengupta
University of Pennsylvania
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Zhifeng Yue
HHMI
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Aalim Weljie
University of Pennsylvania
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Amita Sehgal
HHMI, Perelman School of Medicine at the University of Pennsylvania

Corresponding Author:[email protected]

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Abstract

Sickness sleep and rebound following sleep deprivation share humoral signals including the rise of cytokines, in particular interleukins. Nevertheless, they represent unique physiological states with unique brain firing patterns and involvement of specific circuitry. Here we performed untargeted metabolomics of mouse cortex and hippocampus to uncover acute changes with sickness and rebound sleep as compared to normal daily sleep. We found that the three states are biochemically unique with larger differences in the cortex than in the hippocampus. Both sickness and rebound sleep shared an increase in tryptophan, with the highest levels during sickness. Surprisingly these two sleep states showed stark differences in terms of the energetic signature, with sickness impinging on glycolysis intermediates whilst rebound increased the triphosphorylated form of nucleotides. These findings indicate that rebound following sleep deprivation stimulates an energy rich state in the brain that is devoid during sickness sleep in line with the energy conservation hypothesis of sickness behavior.
29 Mar 2024Submitted to European Journal of Neuroscience
06 Apr 2024Review(s) Completed, Editorial Evaluation Pending
11 Apr 2024Reviewer(s) Assigned
05 Jul 2024Editorial Decision: Revise Major
17 Sep 20241st Revision Received
21 Sep 2024Review(s) Completed, Editorial Evaluation Pending
21 Sep 2024Submission Checks Completed
21 Sep 2024Assigned to Editor
21 Sep 2024Reviewer(s) Assigned
16 Oct 2024Editorial Decision: Accept