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Determination of three ephedrine psychoactive substances in sewage by solid phase extraction-ultra performance liquid chromatography tandem mass spectrometry
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  • Yiqin Xu,
  • Fang Yang,
  • Hong Ye,
  • Qingqiang Tang,
  • Yanwen Chen,
  • Zhigang Gao,
  • Shuhua Wang,
  • Fang Zhang,
  • Xiaojing Li
Yiqin Xu
Fuzhou University College of Environment and Safety Engineering
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Fang Yang
Technology Center of Fuzhou Customs
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Hong Ye
Fuzhou International Travel Healthcare Centre
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Qingqiang Tang
Technology Center of Fuzhou Customs
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Yanwen Chen
Fuzhou International Travel Healthcare Centre
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Zhigang Gao
Fuzhou University College of Environment and Safety Engineering
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Shuhua Wang
Fuzhou University College of Environment and Safety Engineering
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Fang Zhang
Fuzhou University School of Biological Science and Engineering
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Xiaojing Li
Fuzhou University College of Environment and Safety Engineering

Corresponding Author:[email protected]

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Abstract

not-yet-known not-yet-known not-yet-known unknown An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the simultaneous determination of three ephedrine psychoactive substances in water. By optimizing chromatography conditions, mass spectrometry parameters, and solid-phase extraction (SPE) conditions (including the SPE column, sample pH, washing, and elution), the optimal treatment conditions were determined. Poly-Sery MCX was selected as the extraction column, with samples loaded at pH 3. A 4 mL solution of 2% formic acid in water was used as the eluent, and a 5 mL solution of 5% ammonia in acetonitrile was used to elute the target compounds. The best results were obtained when the residue was redissolved in acetonitrile after nitrogen evaporation. The method exhibited a good linear relationship in the range of 0-50.00 μg/L, with determination coefficients (R 2) greater than 0.9990. The detection limit and quantitation limit were 0.05-0.10 μg/L and 0.20-0.50 μg/L, respectively. Recovery rates of the target compounds in blank sewage at three different concentration levels ranged from 92.37% to 106.31%, with relative standard deviations (RSD) of 0.77-4.83% (n=7). This method has been successfully applied to the analysis of surface water and domestic sewage, demonstrating stable treatment effects and practical significance for detecting ephedrine psychoactive substances in water.
Submitted to Rapid Communications in Mass Spectrometry
Submission Checks Completed
Assigned to Editor
Reviewer(s) Assigned
28 Jun 2024Review(s) Completed, Editorial Evaluation Pending
12 Jul 20241st Revision Received
12 Jul 2024Submission Checks Completed
12 Jul 2024Assigned to Editor
12 Jul 2024Review(s) Completed, Editorial Evaluation Pending
12 Jul 2024Reviewer(s) Assigned
20 Jul 2024Editorial Decision: Accept