Iranian crack cocaine decrease immune system function after one-month
administration in rat model
Abstract
Iranian crack cocaine is one of the drugs of abuse used in Iran which
can negatively impact the immune system and its regulation. This study
aims to determine the effect of one month of administration of crack
cocaine on Wistar rats. Methods and materials: Wistar rats were divided
into 4 groups of 10 and received crack injection intraperitoneal for
one, two, and three weeks respectively, and the last group was control
.Blood samples were collected 24 hours after the last injection and
neutrophil and lymphocyte counts were studied using optical microscope.
Results: Neutrophils count decreased significantly after a one-month
crack administration, while Lymphocyte count had a significant increase.
Conclusion: Our findings showed that Iranian crack cocaine can reduce
immune system functions in rat models.