Chlamydia psittaci inhibits the production of reactive oxygen species in
human neutrophils by inhibiting NADPH oxidase through the p38/ERK
signaling pathway
Abstract
Chlamydia psittaci ( C. psittaci) is an obligate
intracellular bacterium that replicates in neutrophils, a significant
producer of reactive oxygen species(ROS). However, the effect of ROS on
C. psittaci infection and whether C. psittaci regulates
ROS production in neutrophils is unclear. When C. psittaci
infects neutrophils, it can induce the production of a small amount of
ROS, affect the assembly of NADPH oxidase through p38/ERK signaling
pathways, and actively block the ROS produced by PMA-stimulated
neutrophils. Importantly, this study may provide new insights into the
molecular pathogenesis and immune escape of C. psittaci.