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Host immune response to respiratory syncytial virus infection in children
  • +5
  • Changhua Yi,
  • Gang Chen,
  • Yi Yan,
  • Jinhuan Wu,
  • Xiuchang Ma,
  • Wenxian Qian,
  • Apeng Chen,
  • Man Tian
Changhua Yi
Second Hospital of Nanjing Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine

Corresponding Author:[email protected]

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Gang Chen
Lianyungang No 1 People's Hospital
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Yi Yan
Children's Hospital of Nanjing Medical University
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Jinhuan Wu
Children's Hospital of Nanjing Medical University
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Xiuchang Ma
Second Hospital of Nanjing Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine
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Wenxian Qian
Second Hospital of Nanjing Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine
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Apeng Chen
Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences
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Man Tian
Children's Hospital of Nanjing Medical University
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Abstract

Respiratory syncytial virus (RSV) is one of the leading causes of severe respiratory diseases in children, especially in infants. The immune responses induced by RSV infection are a fairly complex process that can contribute significantly to disease severity. Despite decades of research on RSV, many immune mechanisms remain to be explored. A full exploration of these immune response can contribute to the discovery of new therapeutic and prophylactic approaches. Despite substantial progress in vaccine development and the development of monoclonal antibodies over the years, there are still not enough effective preventive and therapeutic strategies. This review focuses on how the immune system reacts when children contract the respiratory syncytial virus. We described the biological characteristics of RSV, the pathological process of RSV infection, innate immunity(including Pattern Recognition Receptors and inflammatory cells), adaptive immunity (including CD4+ and CD8+ T cells and Humoral Immune Response), and immune evasion. Understanding the complicated immune response to RSV infection is essential for developing effective interventions and vaccine developments. This review will enable an appreciation of how RSV affects the immune system and enhance the advancement of pragmatic therapeutic methodologies.
14 Mar 2024Submitted to Influenza and other respiratory viruses
03 Sep 2024Review(s) Completed, Editorial Evaluation Pending
09 Sep 2024Editorial Decision: Revise Major
30 Sep 20241st Revision Received
07 Oct 2024Submission Checks Completed
07 Oct 2024Assigned to Editor
28 Oct 2024Reviewer(s) Assigned