Introduction: Post-ablation chest pain is a common occurrence in patients after radiofrequency (RF) pulmonary vein isolation (PVI) ablation for the treatment of atrial fibrillation (AF), with a reported incidence of up to 50%. Pain can be caused by pericarditis, vagal plexus thermal injury, gastroparesis, or local inflammation. Active esophageal cooling is FDA cleared for reducing the likelihood of ablation-related esophageal injury resulting from RF cardiac ablation procedures, but cooling has also been reported to have pleiotropic effects which may mitigate inflammation and reduce the likelihood of post-ablation chest pain. The aim of this study is to quantify the change in incidence of post-ablation chest pain after the adoption of active esophageal cooling during RF ablations. Methods: Data from a community hospital registry were obtained for the 12 months prior to (pre-adoption), and the 12 months after adoption (post-adoption) of active esophageal cooling in December 2021 during RF ablations. Type of ablation was recorded, along with patient’s age, post-ablation symptoms, and type of prophylactic treatment utilized. Incidence rates of chest pain before and after adoption of esophageal cooling were then compared. Results: Data were reviewed from 183 patients. In the pre-adoption cohort, patients were given 2 weeks of daily sucralfate and pantoprazole, with an additional 4 weeks in cases with persisting symptoms. In this group, 90 patients (66.7% persistent AF) with a mean age of 69.6 years (SD ± 10.34) received PVI, with 62 (68.9%) receiving roof lines, 60 (66.7%) receiving floor lines, and 41 (45.6%) reporting post-ablation chest pain requiring extension of treatment to 6 weeks. In the post-adoption cohort, 2 days of sucralfate and pantoprazole was given, and a total of 93 patients (75.2% persistent AF) with a mean age of 68.3 years (SD ± 10.28) received PVI, with 79 (84.5%) receiving roof lines, 75 (80.6%) receiving floor lines, and none reporting post-ablation chest pain (p<0.0001). Conclusion: Adoption of active esophageal cooling was associated with a significant reduction in post-ablation chest pain despite increased use of posterior wall isolation and decreased use of prophylactic treatment.