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The etiologies of hearing loss in Meniere’s disease:Impairment of internal auditory canal barrier
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  • Weidong Zhang,
  • Jiapei Xie,
  • Songbai Li,
  • Bo Zhang
Weidong Zhang
Henan Provincial People's Hospital
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Jiapei Xie
Henan Provincial People's Hospital
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Songbai Li
The First Hospital of China Medical University
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Bo Zhang
The First Hospital of China Medical University

Corresponding Author:[email protected]

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Abstract

Objective: The aim of this investigation was to explore the potential correlation between signal intensity ratio (SIR) at internal auditory canal (IAC) bottom and hearing impairment in MD, thereby providing a foundation for further comprehension of the underlying mechanisms contributing to hearing loss. Design: Fifty patients diagnosed with unilateral definited MD were enrolled in the study. 3D-FLAIR MRI was conducted four hours after intravenous administration of gadobutrol to determine the SIR of bilateral IAC bottom. The difference of SIR of IAC bottom was assessed between affected and unaffected sides, followed by an analysis of its correlation with low-, middle-, and high-tone hearing thresholds. Additionally, correlation analysis was conducted between the degree of EH in vestibular and cochlea and the SIR on the affected side. Results: The degree of EH in MD can be clearly visualized through 3D-FLAIR MRI. The SIR on the affected side was significantly higher than that on the unaffected side (P=0.000). Furthermore, a positive correlation was observed between the SIR at the affected and low (r=0.692, P=0.000), middle (r=0.615, P=0.000) and high-tone (r=0.440, P=0.001); the SIR showed no significant correlation with cochlear (r=0.315, P=0.088) or vestibular hydrops (r=0.215, P=0.244). Conclusion: 3D-FLAIR MRI can observe the degree of EH in MD; impairment of the internal auditory barrier may be one of the factors of hearing loss in MD.
06 Oct 2023Submitted to Clinical Otolaryngology
09 Oct 2023Submission Checks Completed
09 Oct 2023Assigned to Editor
17 Oct 2023Reviewer(s) Assigned
16 Apr 2024Review(s) Completed, Editorial Evaluation Pending
20 Apr 2024Editorial Decision: Revise Major
04 Jun 20241st Revision Received
08 Jun 2024Submission Checks Completed
08 Jun 2024Assigned to Editor
12 Jun 2024Reviewer(s) Assigned
16 Jul 2024Review(s) Completed, Editorial Evaluation Pending
01 Sep 2024Editorial Decision: Revise Minor
19 Sep 20242nd Revision Received
20 Sep 2024Submission Checks Completed
20 Sep 2024Assigned to Editor
20 Sep 2024Review(s) Completed, Editorial Evaluation Pending
22 Sep 2024Editorial Decision: Accept