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Clinical Manifestation and Multidisciplinary Treatment Approaches for Primary Tracheal Carcinoma in Bangladesh: a Clinical and Therapeutic Review of 13 Patients
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  • Qamruzzaman Chowdhury,
  • Md. Rahman,
  • Ferdous Ara Begum,
  • Shariful Islam,
  • Murtaza Khair,
  • Zakir Hossain Sarker,
  • A K M Akramul Haque,
  • Mashud Parvez,
  • Ali Hossain
Qamruzzaman Chowdhury
Bangladesh Specialized Hospitals Limited
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Md. Rahman
Bangladesh Specialized Hospitals Limited

Corresponding Author:[email protected]

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Ferdous Ara Begum
Bangladesh Specialized Hospital Limited, Dhaka, Bangladesh
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Shariful Islam
Delta Medical College and Hospital
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Murtaza Khair
Bangladesh Specialized Hospital Limited, Dhaka, Bangladesh
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Zakir Hossain Sarker
Bangladesh Specialized Hospital Limited, Dhaka, Bangladesh
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A K M Akramul Haque
Bangladesh Specialized Hospital Limited, Dhaka, Bangladesh
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Mashud Parvez
Bangladesh Specialized Hospital Limited
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Ali Hossain
Bangladesh Specialized Hospital Limited, Dhaka, Bangladesh
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Abstract

Introduction: Primary tracheal carcinoma is a rare and challenging disease that presents significant diagnostic and therapeutic difficulties. Delayed diagnosis due to misinterpretation of airway obstruction symptoms often leads to poorer prognoses for patients. This study aimed to explore the clinical manifestations and multidisciplinary treatment approaches for primary tracheal carcinoma in Bangladesh, with a focus on recent advancements in diagnosis and treatment. Methods: A retrospective observational study was conducted at Bangladesh Specialized Hospital Limited, involving patients aged over 30 who were diagnosed with tracheal carcinoma and underwent multidisciplinary treatment. Data were collected through patient interviews and medical record reviews. Descriptive and inferential statistical analyses were performed to examine demographic characteristics, histological variations, tumor locations, clinical signs and symptoms, treatment approaches, and outcomes. Results: Thirteen patients were included in the study, with a mean age of 49.15±10.50 years. The most common histological variations were invasive squamous cell carcinoma and adenoid cystic carcinoma. The upper trachea was the most prevalent tumor location. Dyspnea, cough, and hemoptysis were the most frequently reported symptoms. Surgical interventions, such as definitive surgery and apple coring surgery, were the primary treatment modalities. Multidisciplinary approaches including Adjuvant / definitive Radiotherapy resulted in a low rate of local recurrence, and patients with successful treatment had better survival outcomes. Conclusion: This study provides insights into the demographic and clinical characteristics of primary tracheal carcinoma in Bangladesh and highlights the importance of a multidisciplinary treatment approach. Further research with larger sample sizes is needed to validate these findings and improve diagnostic and therapeutic strategies for this rare malignancy.
15 Sep 2023Submitted to Cancer Reports
03 Oct 2023Submission Checks Completed
03 Oct 2023Assigned to Editor
03 Oct 2023Review(s) Completed, Editorial Evaluation Pending
10 Oct 2023Reviewer(s) Assigned
01 Nov 2023Editorial Decision: Revise Major
16 Mar 20241st Revision Received
20 Mar 2024Assigned to Editor
20 Mar 2024Submission Checks Completed
20 Mar 2024Review(s) Completed, Editorial Evaluation Pending
20 Mar 2024Reviewer(s) Assigned
16 Apr 20242nd Revision Received
17 Apr 2024Submission Checks Completed
17 Apr 2024Assigned to Editor
10 Jun 20243rd Revision Received
11 Jun 2024Submission Checks Completed
11 Jun 2024Assigned to Editor
11 Jun 2024Review(s) Completed, Editorial Evaluation Pending
30 Jun 2024Editorial Decision: Accept