Histologic Features and Decreased Lung FOXF1 Gene Expression in Severe Bronchopulmonary Dysplasia without a Genetic Diagnosis of Alveolar Capillary Dysplasia

Steven Abman H; Csaba Galambos; J. Wells Logan; Pawel Stankiewicz; Przemyslaw  Szafranski; Carola Zalles; Jose Gonzales; Sfurti Nath; Shalinkumar Patel

doi:10.22541/au.167635992.24578122/v1

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Histologic Features and Decreased Lung FOXF1 Gene Expression in Severe Bronchopulmonary Dysplasia without a Genetic Diagnosis of Alveolar Capillary Dysplasia

Steven Abman H,
Csaba Galambos,
J. Wells Logan,
Pawel Stankiewicz,
Przemyslaw Szafranski,
Carola Zalles,
Jose Gonzales,
Sfurti Nath,
Shalinkumar Patel

Abstract

Severe BPD can be associated with clinical and histologic features that are similar to ACD without evidence of FOXF1 genetic disease. Importantly, lung FOXF1 and TMEM100 gene expression is markedly decreased in severe BPD, suggesting that impaired FOXF1 signaling may contribute to abnormal lung growth and refractory pulmonary hypertension in BPD.

14 Feb 2023Submitted to Pediatric Pulmonology

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14 Feb 2023Submission Checks Completed

14 Feb 2023Assigned to Editor

14 Feb 2023Review(s) Completed, Editorial Evaluation Pending

20 Feb 2023Reviewer(s) Assigned

20 Mar 2023Editorial Decision: Revise Major

31 May 20231st Revision Received

02 Jun 2023Submission Checks Completed

02 Jun 2023Assigned to Editor

02 Jun 2023Review(s) Completed, Editorial Evaluation Pending

02 Jun 2023Reviewer(s) Assigned

11 Jun 2023Editorial Decision: Revise Minor

11 Jun 20232nd Revision Received

12 Jun 2023Submission Checks Completed

12 Jun 2023Assigned to Editor

12 Jun 2023Reviewer(s) Assigned

12 Jun 2023Review(s) Completed, Editorial Evaluation Pending

13 Jun 2023Editorial Decision: Accept

Abstract

Peer review status:ACCEPTED