Clinical outcome of individuals carrying 5T;TG12 in trans with CFTR
variants with varying clinical consequences
Abstract
In conclusion, our data suggest that subjects with genotype 5T;TG12/VVCC
likely have a very low risk of progressing to CF, as compared to those
with F508del/5T;TG12. 4 This observation could lead to
differentiate follow up in presence of at least one 5T;TG12. Knowing
these data is crucial to offer a useful counseling for CRMS/CFSPID
infants and for non‐CF adults with CBAVD alone. Anyway further data are
needed to evaluate the outcomes after a longer follow up.