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Breath sound analyses of infants with respiratory syncytial virus-induced acute bronchiolitis
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  • Kenta Kuruma,
  • Tomofumi Otomo,
  • Takashi Sakama,
  • Kousuke Akiyama,
  • Hiromitsu Takakura,
  • Daisuke Toyama,
  • Kota Hirai,
  • Hiroyuki Furuya,
  • Masahiko Kato,
  • Hiroyuki Mochizuki
Kenta Kuruma
Tokai University Hachioji Hospital

Corresponding Author:[email protected]

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Tomofumi Otomo
Tokai University Hachioji Hospital
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Takashi Sakama
Tokai University Hachioji Hospital
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Kousuke Akiyama
Tokai University Hachioji Hospital
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Hiromitsu Takakura
Tokai University Hachioji Hospital
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Daisuke Toyama
Tokai University Hachioji Hospital
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Kota Hirai
Tokai University Hachioji Hospital
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Hiroyuki Furuya
Tokai University School of Medicine
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Masahiko Kato
Tokai Daigaku Igakubu
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Hiroyuki Mochizuki
Tokai University School of Medicine
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Abstract

Introduction: The reliability of breath sound analysis using an improved method in infants has been reported. Objective: Breath sounds of infants with respiratory syncytial virus (RSV)-induced acute bronchiolitis were analyzed to evaluate their specificity and examine their relationship with the severity. Subjects and methods: We evaluated the inspiratory and expiratory breath sound parameters of 33 infants (median age=2 months old) diagnosed with RSV-induced acute bronchiolitis. The sound powers of inspiration and expiration and the spectrum curve indices (ratio of the third and fourth area to the total area under the curve and ratio of the power and frequency at 50% and 75% of the highest frequency were evaluated at the acute phase and recovery phase. Furthermore, the relationship between the breath sound parameters and the clinical severity of acute bronchiolitis was examined. Results: Analyses of the breath sound spectrogram showed that the power of expiration at the acute phase was large, and was the expiration-to-inspiration sound power ratio in a mid-frequency range (E/I MF), with values decreased in the recovery phase. Data of the inspiratory sound spectrum curve showed the improvement of airway stenosis during the recovery period. Furthermore, there were significant relationships between the E/I MF and SpO2 and the severity score of acute bronchiolitis. Conclusion: In RSV-induced acute bronchiolitis, specificity of breath sounds was observed in the expiration sound and the reversible airway stenosis was evaluated. Breath sound analyses are expected to be useful for the diagnosis and clinical evaluation of the severity of acute bronchiolitis.
21 Jan 2022Submitted to Pediatric Pulmonology
21 Jan 2022Submission Checks Completed
21 Jan 2022Assigned to Editor
23 Jan 2022Reviewer(s) Assigned
15 Mar 2022Review(s) Completed, Editorial Evaluation Pending
29 Mar 2022Editorial Decision: Revise Major
17 Apr 20221st Revision Received
18 Apr 2022Submission Checks Completed
18 Apr 2022Assigned to Editor
18 Apr 2022Reviewer(s) Assigned
16 May 2022Review(s) Completed, Editorial Evaluation Pending
25 May 2022Editorial Decision: Revise Minor
02 Jun 20222nd Revision Received
03 Jun 2022Submission Checks Completed
03 Jun 2022Assigned to Editor
03 Jun 2022Reviewer(s) Assigned
03 Jun 2022Review(s) Completed, Editorial Evaluation Pending
06 Jun 2022Editorial Decision: Accept
21 Jun 2022Published in Pediatric Pulmonology. 10.1002/ppul.26034