Late relapse of IgM nephropathy-associated nephrotic syndrome after
repeated administration of immune checkpoint inhibitor against pulmonary
adenocarcinoma
Abstract
A man aged 60’s suffered nephrotic syndrome with IgM nephropathy seven
years earlier. Four years later, immune-checkpoint inhibitors (ICPIs)
were administered against metastasizing pulmonary adenocarcinoma.
Sixty-two weeks after 21 ICPIs injections, the cancer vanished but
nephrotic syndrome relapsed. Acute pancreatitis followed and usual
interstitial pneumonia exacerbated, as late-onset immune-related
adverse-events.
