Modeling the impact of space weather events such as coronal mass ejections (CMEs) is crucial to protecting critical infrastructure. The Space Weather Modeling Framework (SWMF) is a state-of-the-art framework that offers full Sun-to-Earth simulations by computing the background solar wind, CME propagation and magnetospheric impact. However, reliable long-term predictions of CME events require uncertainty quantification (UQ) and data assimilation (DA). We take the first steps by performing global sensitivity analysis (GSA) and UQ for background solar wind simulations produced by the Alfvén Wave Solar atmosphere Model (AWSoM) for two Carrington rotations: CR2152 (solar maximum) and CR2208 (solar minimum). We conduct GSA by computing Sobol indices that quantify contributions from model parameter uncertainty to the variance of solar wind speed and density at 1 au, both crucial quantities for CME propagation and strength. Sobol indices also allow us to rank and retain only the most important parameters, which aids in the construction of smaller ensembles for the reduced-dimension parameter space. We present an efficient procedure for computing the Sobol indices using polynomial chaos expansion (PCE) surrogates and space-filling designs. The PCEs further enable inexpensive forward UQ. Overall, we identify three important model parameters: the multiplicative factor applied to the magnetogram, Poynting flux per magnetic field strength constant used at the inner boundary, and the coefficient of the perpendicular correlation length in the turbulent cascade model in AWSoM.