Laboratory studies suggest that seismogenic rupture on faults in carbonate terrains can be explained by a transition from high friction, at low sliding velocities (V), to low friction due to rapid dynamic weakening as seismic slip velocities are approached. However, consensus on the controlling physical processes is lacking. We previously proposed a microphysically-based model (the ‘Chen-Niemeijer-Spiers’ model) that accounts for the (rate-and-state) frictional behavior of carbonate fault gouges seen at low velocities characteristic of rupture nucleation. In the present study, we extend the CNS model to high velocities (1mm/s≤ V ≤10m/s) by introducing multiple grain-scale deformation mechanisms activated by frictional heating. As velocity and hence temperature increase, the model predicts a continuous transition in dominant deformation mechanisms, from frictional granular flow with partial accommodation by plasticity at low velocities and temperatures, to grain boundary sliding with increasing accommodation by solid-state diffusion at high velocities and temperatures. Assuming that slip occurs in a localized shear band, within which grain size decreases with increasing velocity, the model results capture the main mechanical trends seen in high-velocity friction experiments on room-dry calcite-rich rocks, including steady-state and transient aspects, with reasonable quantitative agreement and without the need to invoke thermal decomposition or fluid pressurization effects. The extended CNS model covers the full spectrum of slip velocities from earthquake nucleation to seismic slip rates. Since it is based on realistic fault structure, measurable microstructural state variables and established deformation mechanisms, it offers an improved basis for extrapolating lab-derived friction data to natural fault conditions.